Vice President, Clinical Development (Oncology & Molecular Diagnostics)

<h3><span style="color: #000000;"><strong>Vice President, Clinical Development (Oncology & Molecular Diagnostics)</strong></span></h3> <p><span style="color: #000000;"><strong>Reports to:</strong> Chief Medical Officer, Corporate</span></p> <p><span style="color: #000000;"><strong>Location:</strong> United States (Remote, with up to 30% travel)</span></p> <p><span style="color: #000000;"><strong>Position Summary</strong></span></p> <p><span style="color: #000000;">Natera is seeking a Vice President of Clinical Development to deliver absolute ownership over the strategy, design, and execution of Natera-sponsored clinical studies. This corporate leader will institutionalize clinical trial architecture across the enterprise, distinct from therapeutic area strategy, with an immediate focus on defending and expanding our oncology footprint (including Early Cancer Detection and Signatera MRD), alongside corporate-level support for Women's Health and Organ Health.</span></p> <p><span style="color: #000000;">Reporting directly to the Chief Medical Officer, you will be accountable for the operational health, scientific validity, and clinical utility data generated by Natera’s multi-million dollar sponsored study portfolio. This is a high-autonomy role for a builder who can navigate rapid structural transitions—specifically our evolution from a Laboratory Developed Test (LDT) framework into highly regulated FDA In Vitro Diagnostic (IVD) and Companion Diagnostic (CDx) pharma partnerships.</span></p> <p><span style="color: #000000;"><strong>Key Responsibilities</strong></span></p> <ul> <li style="color: #000000 !important;"><span style="color: #000000;"><strong>Portfolio Architecture & Governance:</strong> Establish and enforce portfolio-level governance models to monitor study health, site enrollment, milestone delivery, sample flow, and data readiness. Make definitive, data-driven go/no-go decisions on trial modifications, accelerations, or terminations based on objective strategic value and execution feasibility.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;"><strong>Clinical Utility Design:</strong> Lead cross-functional teams to design high-impact prospective, observational, and decision-impact trials. Translate clinical questions into protocols that explicitly isolate and prove clinical validity, analytical validity, and decision-impact endpoints to secure broad commercial payer coverage and medical guideline inclusion.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;"><strong>Regulatory & CDx Alignment:</strong> Partner with Regulatory affairs to build clinical evidence strategies that support FDA pre-market approval (PMA), 510(k), and De Novo pathways. Lead intended-use claim strategy and protocols that support companion diagnostic (CDx) co-development with biopharma partners.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;"><strong>Operational Study Health:</strong> Direct internal Clinical Operations and external CROs to eliminate bottlenecks in site activation, sample transit degradation, and query resolution. Implement fast, corrective action plans for under-performing sites or delayed protocols.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;"><strong>Scientific Footprint & Influence:</strong> Maintain and build a direct, peer-to-peer scientific relationship with leading academic investigators, cooperative groups, and guideline panel members. Personally author and contribute to landmark peer-reviewed publications and abstract presentations at major oncology and diagnostic symposia.</span></li> </ul> <p><span style="color: #000000;"><strong>Qualifications</strong></span></p> <ul> <li style="color: #000000 !important;"><span style="color: #000000;">MD, MD/PhD, or PhD with equivalent oncology pivotal or registrational trial leadership experience.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">18+ years of experience in clinical development, clinical research, or clinical evidence generation, including at least 10 years personally directing oncology clinical trials.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Diagnostics-native fluency: deep, unassisted comfort discussing cell-free DNA (cfDNA), ctDNA dynamics, minimal residual disease (MRD), analytical vs. clinical validity, and decision-impact metrics.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Demonstrated experience operating cross-functionally within a highly matrixed environment with direct authority over clinical portfolios.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Proven track record of designing evidence strategies that directly influenced regulatory submissions, multi-site registries, or national coverage determinations (LCDs/payors).</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">High tolerance for ambiguity and an active bias for action; comfortable making critical portfolio trade-offs with incomplete information.</span></li> </ul> <p> </p><div class="content-pay-transparency"><div class="pay-input"><div class="description">The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.</div><div class="title">Remote USA</div><div class="pay-range"><span>$350,000</span><span class="divider">—</span><span>$430,000 USD</span></div></div></div><div class="content-conclusion"><p><strong>OUR OPPORTUNITY</strong></p> <p>Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.</p> <p>The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.</p> <p><strong>WHAT WE OFFER</strong></p> <p>Competitive Benefits - Employee benefits include comprehensive medical, d